The purpose of the present pilot study is to find out the effect of AYUSH approved Diabetic Yoga Protocol on glycemic, anthropometric and neuropsychological profile of high-risk women for Diabetes. The high-risk women for Diabetes were identified by using the Indian Diabetes Risk Score. Total ten high-risk women for Diabetes selected from urban area of Chandigarh were recruited in the study for 12 weeks. Single group experimental research design was used. The changes in glycemic, anthropometric and neuropsychological parameters were examined at baseline and after 12 weeks changes after DYP intervention. The result of the present study demonstrated that after 3 months of DYP intervention the statistically significant changes were seen on Fating blood glucose (p=0.041), hip circumference (p=0.007) and perceived stress (p<0.001) whereas no changes were seen on sustained attention, waist circumference and weight of the high risk women for Diabetes in urban area of Chandigarh.